![]() These include ethological, conflict-based, hyponeophagia, vocalization-based, physiological and cognitive-based paradigms. In this paper, we describe some of the more widely used approaches for assessing the anxiolytic activity of known and potential therapeutic agents. In particular, the heterogeneous nature of anxiety disorders in humans coupled with the associated multifaceted and descriptive diagnostic criteria, creates challenges in both animal modelling and in clinical research. The approach, however, is challenged with a number of complexities. Animal models are an important aid in giving insight into the aetiology, neurobiology and, ultimately, the therapy of human anxiety disorders. However, the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most psychiatric disorders, remain relatively poorly understood. ![]() Anxiety disorders are common, serious and a growing health problem worldwide.
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